The R1 side chain is the major factor for cross-reactivity due to antibody recognition between cephalosporins and penicillins. Cross-reactivity with cefazolin or carbapenems is very unlikely …
Cefazolin does not share a sidechain with any penicillins or cephalosporins available in the US and can be used in patients with a history of beta-lactam allergy regardless of symptoms.[7]
Note that a patient could have an allergic reaction to a dissimilar beta-lactam; however this likely represents a second allergic reaction, not cross-reactivity of the parent allergen.
AVOID ALL beta-lactam antibiotics if: ICU admission related to allergy Delayed beta-lactam antibiotic allergy causing: interstitial nephritis hepatitis hemolytic anemia
The NM -lactam cross-reactivity side chain chart is a guide and should be used with the NM -lactam Allergy Risk Assessment and Clinical Pathway for Outpatients or Non-Critically Ill …
Cross-reactivity: β-lactams include penicillins, cephalosporins, and carbapenems. These drugs all consist of a β-lactam ring but difer in their additional side chains. Traditionally, it was thought …
NM Beta Lactam Cross Reaction Table
The NM -lactam cross-reactivity side chain chart is a guide and should be used with the NM -lactam Allergy Risk Assessment and Clinical Pathway for Outpatients or Non-Critically Ill …
a: Applies to amoxicillin-clavulanate and ampicillin-sulbactam b: Ceftazidime and Ceftolozane share a side-chain with aztreonam and cross-reactivity is possible. Avoid agents.
Discrepancies in Beta-Lactam Antibiotics Cross-Reactivity: …
Studies previously published on BA cross-reactivity use different sets of BA and seem to contain conflicting recommendations on safe BA alternatives in case of (suspected) BA allergy.
The NM beta-lactam cross-reactivity side chain chart is a guide and should be used with the NM beta-lactam Allergy Risk Assessment and Clinical Pathway for Outpatients or Non-Critically Ill …