'Lock-and-key' chemistry keeps cancer drugs inactive until they reach tumor sites

Many therapeutic molecules used in cancer treatments are highly toxic, often harming healthy tissues and causing significant ...
SciELO

Implementation of criteria for automatic release of clinical chemistry test results in a laboratory at an academic public hospital

Introduction: Autoverification is the release of laboratory test results from clinical instruments to hospital interface, or to patients' records, with no human intervention. Verification rules are ...
Journal of Medical Internet Research

How to Design, Create, and Evaluate an Instruction-Tuning Dataset for Large Language Model Training in Health Care: Tutorial From a Clinical Perspective

This tutorial provides a comprehensive guide to designing, creating, and evaluating ITDs for health care applications. Written from a clinical perspective, it aims to make the concepts accessible to a ...
C&EN

Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers

Discovery Technologies, Medicinal Chemistry, EMD Serono Research & Development Institute, Inc., Billerica, Massachusetts 01821, United States ...