A study shows that high levels of negatively charged lipids can lock growth receptors into an overactive state, driving ...

CD8+ T cells divide cysteine between pathways that control growth and cancer-killing activity. Adjusting its use can enhance ...

In complex diseases, many different genetic changes can push cells into the same harmful state, as is the case with melanoma ...

PerturbFate can systematically map how diverse disease-associated genetic variations reshape cells to understand complex diseases, like cancer.

Mayo Clinic scientists are exploring an unusual but promising strategy to treat one of the deadliest bile duct cancers by turning milk into a microscopic delivery system for gene therapy. Their work ...

Leucine-rich repeat-containing 8A (LRRC8A) is a ubiquitously expressed transmembrane protein that functions as the essential ...

A research team has discovered a new mechanism and drug combination strategy that can effectively treat osteoporosis, a ...

Seemingly unrelated diseases and conditions like Alzheimer's disease, obesity, chronic pain, traumatic brain injury, and ...

A new platform for studying mtDNA mutations implicated in human disease could help accelerate treatments for mitochondrial ...

Local researcher will work with wide range of institutions, including UCSD, Scripps Research, Duke University and MIT, to use ...

This paper provides a valuable observation that imiquimod, a compound often used to induce a psoriasis-like skin inflammation in mice, has a TLR7-independent effect acting through the unfolded protein ...