The ability of different genetic variants—changes to one or more building blocks of DNA—to cause disease, and to what extent, has historically been opaque. Geneticist and Crick group leader Greg ...

Mutations in a single gene, HNF1A, are known to cause MODY3, a rare, early onset form of diabetes. Smaller scale mutations in the very same gene are also common and quietly nudge millions of people ...

KRAS is the most frequently mutated oncogene across all human cancers. Although different KRAS mutations have long been thought to exert the same cancer-driving effects, a new study led by UT ...

It’s well established that some cases of amyotrophic lateral sclerosis (ALS) are caused by mutations that are inherited from a person’s parents — but a new study shows some cases of sporadic ALS may ...

Cerebrospinal fluid circulating tumor DNA for the detection and characterization of leptomeningeal metastasis in non-small cell lung cancer. This is an ASCO Meeting Abstract from the 2023 ASCO Annual ...

In the children’s game telephone, a whispered phrase like “I ate a pear” can quickly become “I hate bears” as it moves down a line of players. As genes are passed down from parents to offspring, they ...