Immunotherapy using modified chimeric antigen receptor (CAR) T cells has improved survival rates for pediatric patients with relapsed and recurrent leukemia. However, these therapies are not as ...

CAR-T cell therapy has emerged as a transformative approach in treating B cell malignancies and multiple myeloma. However, this approach is in desperate need of refinement. While attacking tumor cells ...

Cytokines are key to immune regulation. Their extensive impact on human biology and disease has led to their long-term therapeutic use in treating cancer and a range of other diseases. Interleukin-2 ...

Sanofi’s success co-developing a blockbuster drug based on blocking the signaling of interleukin 4 and interleukin 13 (IL-4 and IL-13) makes it an ideal partner to collaborate on inflammatory ...

Current cell therapies like CAR-T cells lack the precision to distinguish between healthy and diseased tissue, leading to limited effectiveness and potential side effects. One of the most significant ...

In the broadest sense, immunomodulators are drugs that adjust immune responses, for example, modulation of cytokine levels. Cytokines are signaling proteins responsible for the regulation of immune ...

Psoriasis, a chronic inflammatory skin condition characterized by dry and scaly skin lesions, affects about 7.5 million people in the United States. Psoriasis results from abnormal proliferation of ...

Advances in biotechnology, a greater understanding of the immunopathogenesis of rheumatoid arthritis (RA) and a desire for more effective therapeutics have led to the development of a class of ...

Cytokines play a central role in regulating physiological processes, largely because of their ability to orchestrate intercellular communication. As ...