A microorganism whose evolutionary roots can be traced to the era of the first multicellular animals may provide a glimpse of how single-celled organisms made a critical evolutionary leap. In ...

LaBonne is president of the Society for Developmental Biology and the Erastus Otis Haven professor of molecular biosciences at Northwestern University. Imagine a world without lifesaving medicines, ...

Animal models are established, important tools for preclinical safety and efficacy testing. Companies are advancing more “humanized” models to better reflect human responses, while at the same time ...

Embryonic germ layers are the fundamental organizing principle in animal development. They provide the structural basis from which tissues and organs arise. During early embryogenesis, cells divide to ...

Visit NAP.edu/10766 to get more information about this book, to buy it in print, or to download it as a free PDF. 1 As discussed in Chapter 2, current animal models do not adequately reflect the human ...